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Save $25 on a year's supply.

#1 Prescribed Canine Combination Parasiticide

Available by prescription from your veterinarian.

Our mail-in rebate makes it easy to give your dog effective parasite protection for less.

Save $25 on a year's supply.

Available by prescription from your veterinarian.

Protect Your Dog from Parasites with Trifexis^® (spinosad + milbemycin oxime)

Parasites can be practically anywhere your dog goes — including your home and yard. They pose a serious threat to your dog’s health. That’s why you need to make sure your dog is protected.

Luckily, Trifexis makes it easy to give your dog powerful 3-in-1 parasite protection.

Trifexis is a once-monthly tablet that:

Kills fleas and prevents infestations
Prevents heartworm disease
Treats and controls adult hookworm, roundworm and whipworm infections

Trifexis combines two powerful active ingredients that are safe and effective at protecting against three types of dangerous parasites. And since it is given orally, there is no need to isolate your dog from your kids or other pets.

Now effective parasite protection is just one and done — once a month, every month.

Learn more about Trifexis and why it might be the right parasite treatment and preventive for your dog.

Flea control and your dog.

Flea Control and Your Dog

Protecting your dog from heartworm disease.

Protecting Your Dog from Heartworm Disease

Warding off intestinal parasites

Warding Off Intestinal Parasites

Other pets in your family?

Learn more about Elanco’s other pet products .

The safety of Trifexis in the news

If you are a concerned pet owner, please see our Safety Facts page for more information and please speak with your veterinarian. If you are a member of the media and wish to speak with someone in Elanco Media Relations please call, 1-877-352-6261.

Trifexis Safety Facts

Email Reminder

Email and Text Message Reminders

Receive an email or text message reminder from your dog when it is time to give Trifexis.

Keep Your Pet Safe

Trifexis has demonstrated its safety when used as directed on the label. Learn more.
Like all medications, sometimes side effects occur. If you suspect your dog has had an adverse reaction to Trifexis, please call 1-888-545-5973.
Find out why choosing Trifexis can protect your dog from fleas, heartworm, and intestinal parasites. Learn more.

DVM and Staff Site

Important Safety Information

Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis chewable tablets.

Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy.

The most common adverse reactions reported are vomiting, depression/lethargy, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting.

View full product label for complete safety information.

References

1. Vet Insite Analytics. Based on total canine combination parasiticide product data (flea, tick, heartworm), 06/2014

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